STIL

Across TCGA cell cohorts, STIL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,542 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STIL-associated GO terms across cancer lineages are Regulation of G2/M transition of mitotic cell cycle, Regulation of centrosome duplication, and Negative regulation of cell cycle process. Each is linked with STIL in more than 19 cancer types. Because this analysis shows association rather than direction, both STIL-to-partner and partner-to-STIL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of G2/M transition of mitotic cell cycle grouped by STIL-low versus STIL-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STIL→partner) and Y-score (partner→STIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of G2/M transition of mitotic cell cycle →	+0.073	+0.793	.001	<.001	3	20
LUNG_SCLC	Regulation of centrosome duplication →	+0.107	+0.886	<.001	<.001	3	20
BREAST	Negative regulation of cell cycle process →	+0.059	+0.918	<.001	<.001	3	20
OESOPHAGUS	Spindle elongation →	+0.271	+1.119	.001	<.001	3	20
BONE	Chromosome segregation →	+0.103	+1.090	.008	.002	3	20
URINARY_TRACT	Positive regulation of cell cycle process →	+0.096	+0.955	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,542 associations by consensus.

Regulation of G2/M transition of mitotic cell cycle by STIL expression — OVARY

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