STIL

Across TCGA cell cohorts, STIL mutation is significantly associated with the RNA expression of many other genes, with 569 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STIL-associated genes across cancer lineages are OR1J2, THAP6, and MYO1C. Each is linked with STIL in more than 1 cancer types. Because this analysis shows association rather than direction, both STIL-to-partner and partner-to-STIL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1J2 grouped by STIL-low versus STIL-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STIL→partner) and Y-score (partner→STIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR1J2 →	+0.049	+2.669	.003	.005	3	2
LARGE_INTESTINE	THAP6 →	+0.594	+3.169	<.001	.009	3	2
LARGE_INTESTINE	MYO1C →	+0.803	+3.169	.002	.009	3	2
LARGE_INTESTINE	FAM169A →	+1.008	+3.502	.005	.001	3	2
BLOOD_Myeloma	OR6X1 →	+0.020	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUAD	LIM2 →	+0.014	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 569 associations by consensus.

OR1J2 by STIL expression — BLOOD_Leukemia

Explore this box plot interactively →