STH

Across TCGA cell cohorts, STH RNA expression is significantly associated with the go_rna of many other GO terms, with 2,099 significant associations in total. BONE shows the largest number of these associations.

The most reproducible STH-associated GO terms across cancer lineages are Nucleoside triphosphate biosynthetic process, Purine ribonucleotide biosynthetic process, and Constitutive heterochromatin formation. Each is linked with STH in more than 6 cancer types. Because this analysis shows association rather than direction, both STH-to-partner and partner-to-STH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleoside triphosphate biosynthetic process grouped by STH-low versus STH-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STH→partner) and Y-score (partner→STH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Nucleoside triphosphate biosynthetic process →	+0.077	+0.305	.001	.001	3	7
BONE	Purine ribonucleotide biosynthetic process →	+0.061	+0.446	.007	.003	3	6
BREAST	Constitutive heterochromatin formation →	+0.055	+0.287	.001	.006	3	5
BONE	Regulation of leukocyte proliferation →	-0.079	-0.695	.002	.002	3	5
BONE	Regulation of response to wounding →	-0.128	-0.668	<.001	<.001	3	5
LUNG_SCLC	ATP metabolic process →	+0.077	+0.333	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,099 associations by consensus.

Nucleoside triphosphate biosynthetic process by STH expression — LUNG_SCLC

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