STEAP4

Across TCGA patient cohorts, STEAP4 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STEAP4-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and Gab2. Each is linked with STEAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both STEAP4-to-partner and partner-to-STEAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by STEAP4-low versus STEAP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STEAP4→partner) and Y-score (partner→STEAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.135	+2.000	.047	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.697	+2.321	<.001	<.001	3	2
SKCM	Gab2 →	-0.464	-2.115	.007	.018	3	1
SKCM	SCD →	+0.160	+1.787	.011	.045	3	1
SKCM	cIAP →	+0.143	+2.195	.025	.032	3	1
UCEC	14-3-3_beta →	-0.083	-2.673	.010	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eIF4E by STEAP4 expression — UCEC

Explore this box plot interactively →