STEAP4

Across TCGA pan-cancer cohorts, STEAP4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of STEAP4’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where STEAP4 RNA is repressed in tumor relative to normal tissue. In most cancer types STEAP4 is over-expressed in tumor, although a few such as LUSC and LIHC show the opposite, repressed pattern.

LUSC, LIHC, and COAD are the cancer types where STEAP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STEAP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−4.295	<.001	8	view →
LIHC	Female	All	−1.233	<.001	8	view →
COAD	All	All	−0.635	<.001	8	view →
KICH	Male	II,III,IV	−1.775	<.001	7	view →
KIRC	Female	All	+1.481	<.001	7	view →
BLCA	All	All	−1.471	.001	7	view →
UCEC	All	III,IV	−2.383	<.001	6	view →
BRCA	All	III,IV	−2.190	<.001	6	view →
HNSC	Male	II,III,IV	−1.542	<.001	5	view →
LUAD	All	All	−0.888	<.001	5	view →
KIRP	All	All	−0.618	.004	3	view →
THCA	All	All	+0.412	.009	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

STEAP4–LUSC

Open the LUSC breakdown →