STEAP4

Across TCGA cell cohorts, STEAP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,700 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible STEAP4-associated GO terms across cancer lineages are Establishment of endothelial intestinal barrier, Adenylate cyclase-modulating G protein-coupled receptor signaling pathway, and Regulation of hippocampal neuron apoptotic process. Each is linked with STEAP4 in more than 9 cancer types. Because this analysis shows association rather than direction, both STEAP4-to-partner and partner-to-STEAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of endothelial intestinal barrier grouped by STEAP4-low versus STEAP4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STEAP4→partner) and Y-score (partner→STEAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Establishment of endothelial intestinal barrier →	+0.138	+1.069	.001	.007	3	10
BREAST	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.059	-2.893	<.001	<.001	3	10
URINARY_TRACT	Regulation of hippocampal neuron apoptotic process →	+2.304	+2.388	<.001	.002	3	9
URINARY_TRACT	Negative regulation of hippocampal neuron apoptotic process →	+2.141	+2.388	<.001	.002	3	9
URINARY_TRACT	Positive regulation of iron ion transport →	+2.218	+2.671	<.001	.001	3	9
URINARY_TRACT	Positive regulation of iron ion transmembrane transport →	+2.218	+2.671	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,700 associations by consensus.

Establishment of endothelial intestinal barrier by STEAP4 expression — LARGE_INTESTINE

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