STEAP4

Across TCGA cell cohorts, STEAP4 mutation is significantly associated with the RNA expression of many other genes, with 240 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STEAP4-associated genes across cancer lineages are FTMT, OR1C1, and MROH5. Each is linked with STEAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both STEAP4-to-partner and partner-to-STEAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTMT grouped by STEAP4-low versus STEAP4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STEAP4→partner) and Y-score (partner→STEAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR1C1 →	+0.091	+4.930	<.001	.008	3	1
SOFT_TISSUE	MROH5 →	+0.028	+4.930	<.001	.008	3	1
BLOOD_Lymphoma	ADIPOQ →	+0.006	+5.209	.006	.005	3	1
SKIN	C7orf33 →	+0.057	+3.632	<.001	.003	3	1
SKIN	FOXE3 →	+0.088	+3.453	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 240 associations by consensus.

FTMT by STEAP4 expression — SOFT_TISSUE

Explore this box plot interactively →