STEAP2

Across TCGA cell cohorts, STEAP2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STEAP2-associated genes across cancer lineages are C20orf141, C10orf71, and C5orf52. Each is linked with STEAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STEAP2-to-partner and partner-to-STEAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf141 grouped by STEAP2-low versus STEAP2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STEAP2→partner) and Y-score (partner→STEAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C20orf141 →	+0.106	+4.807	<.001	.006	3	1
CNS	C10orf71 →	+0.016	+4.981	<.001	.008	3	1
SKIN	C5orf52 →	+0.062	+6.000	<.001	<.001	3	1
SKIN	GALP →	+0.017	+4.415	<.001	.007	3	1
SKIN	NPS →	+0.276	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR4F4 →	+0.018	+3.103	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

C20orf141 by STEAP2 expression — BLOOD_Myeloma

Explore this box plot interactively →