STEAP1B

Across TCGA patient cohorts, STEAP1B mutation is significantly associated with the RNA expression of many other genes, with 860 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STEAP1B-associated genes across cancer lineages are MDH1P2, SS18L2P1, and ARHGEF38-IT1. Each is linked with STEAP1B in more than 1 cancer types. Because this analysis shows association rather than direction, both STEAP1B-to-partner and partner-to-STEAP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDH1P2 grouped by STEAP1B-low versus STEAP1B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STEAP1B→partner) and Y-score (partner→STEAP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MDH1P2 →	+0.058	+5.279	<.001	.006	3	2
CESC	SS18L2P1 →	+0.255	+5.306	<.001	.006	3	2
UCEC	ARHGEF38-IT1 →	+0.600	+2.436	<.001	.002	3	2
COAD	MARCHF11-AS1 →	+0.234	+6.917	.003	<.001	3	2
COAD	TSEN2P1 →	+0.238	+5.017	<.001	.009	3	2
COAD	TRIM48 →	+0.196	+6.392	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 860 associations by consensus.

MDH1P2 by STEAP1B expression — LUAD

Explore this box plot interactively →