STEAP1B

Across TCGA pan-cancer cohorts, STEAP1B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of STEAP1B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where STEAP1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STEAP1B is over-expressed in tumor, although a few such as BRCA and COAD show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where STEAP1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STEAP1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+1.712	<.001	12	view →
KIRC	Male	IV	+0.427	<.001	9	view →
LIHC	All	All	+0.159	<.001	9	view →
LUSC	All	II,III,IV	+1.626	<.001	7	view →
LUAD	Male	All	+1.061	<.001	7	view →
BRCA	All	III,IV	−0.388	<.001	6	view →
CHOL	All	II,III,IV	+0.300	.004	3	view →
KIRP	All	II,III,IV	+0.313	.026	2	view →
THCA	All	III,IV	+0.146	.024	2	view →
COAD	Female	IV	−0.150	.002	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

STEAP1B–HNSC

Open the HNSC breakdown →