STEAP1B

Across TCGA patient cohorts, STEAP1B mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STEAP1B-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and Notch1. Each is linked with STEAP1B in more than 1 cancer types. Because this analysis shows association rather than direction, both STEAP1B-to-partner and partner-to-STEAP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by STEAP1B-low versus STEAP1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STEAP1B→partner) and Y-score (partner→STEAP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.235	-2.000	.038	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.173	-3.169	.023	.019	3	1
UCEC	Notch1 →	+0.129	+3.013	.042	.018	3	1
UCEC	p62 Lck ligand →	+0.351	+3.009	.016	.019	3	1
UCEC	Annexin-1 →	+0.596	+2.000	.011	.032	3	1
UCEC	TIGAR →	+0.227	+3.833	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by STEAP1B expression — UCEC

Explore this box plot interactively →