STEAP1B

Across TCGA cell cohorts, STEAP1B mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible STEAP1B-associated genes across cancer lineages are OR2D3, KRTAP10-7, and C20orf173. Each is linked with STEAP1B in more than 1 cancer types. Because this analysis shows association rather than direction, both STEAP1B-to-partner and partner-to-STEAP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2D3 grouped by STEAP1B-low versus STEAP1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STEAP1B→partner) and Y-score (partner→STEAP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2D3 →	+0.024	+4.095	.003	.009	3	2
LUNG_NSCLC_LUAD	KRTAP10-7 →	+0.015	+4.078	<.001	.009	3	2
BONE	C20orf173 →	+0.024	+4.672	<.001	.001	3	1
BONE	SLC6A5 →	+0.024	+4.307	<.001	.004	3	1
BONE	CCDC182 →	+0.020	+4.169	<.001	.008	3	1
BONE	VN1R3 →	+0.035	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

OR2D3 by STEAP1B expression — LARGE_INTESTINE

Explore this box plot interactively →