STC2

Across TCGA patient cohorts, STC2 mutation is significantly associated with the RNA expression of many other genes, with 1,796 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STC2-associated genes across cancer lineages are GOLM1, PTP4A3, and ZNF79. Each is linked with STC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both STC2-to-partner and partner-to-STC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOLM1 grouped by STC2-low versus STC2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STC2→partner) and Y-score (partner→STC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GOLM1 →	+0.732	+3.335	.002	.005	3	3
UCEC	PTP4A3 →	-0.778	-2.502	.001	.002	3	2
UCEC	ZNF79 →	+0.435	+2.716	<.001	.003	3	2
UCEC	ADA →	-0.611	-3.438	.003	.005	3	2
UCEC	SHPK →	+0.500	+3.180	<.001	<.001	3	2
UCEC	FLVCR1-DT →	+0.451	+2.633	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,796 associations by consensus.

GOLM1 by STC2 expression — COAD

Explore this box plot interactively →