STATH

Across TCGA patient cohorts, STATH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,865 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible STATH-associated GO terms across cancer lineages are Negative regulation of canonical Wnt signaling pathway, Positive regulation of osteoblast differentiation, and Prostate gland morphogenesis. Each is linked with STATH in more than 6 cancer types. Because this analysis shows association rather than direction, both STATH-to-partner and partner-to-STATH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of canonical Wnt signaling pathway grouped by STATH-low versus STATH-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STATH→partner) and Y-score (partner→STATH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Negative regulation of canonical Wnt signaling pathway →	+0.074	+0.012	<.001	<.001	3	7
TGCT	Positive regulation of osteoblast differentiation →	+0.066	+0.012	<.001	<.001	3	7
TGCT	Prostate gland morphogenesis →	+0.101	+0.019	<.001	.001	2	7
TGCT	Positive regulation of biomineral tissue development →	+0.040	+0.012	.001	.001	3	6
STAD	Regulation of synaptic vesicle cycle →	+0.046	+0.139	<.001	.001	3	6
TGCT	Regulation of epithelial to mesenchymal transition →	+0.073	+0.015	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,865 associations by consensus.

Negative regulation of canonical Wnt signaling pathway by STATH expression — TGCT

Explore this box plot interactively →