STATH

Across TCGA pan-cancer cohorts, STATH RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of STATH’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where STATH RNA is repressed in tumor relative to normal tissue. In most cancer types STATH is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC, LUSC, and KIRC are the cancer types where STATH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STATH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−5.026	<.001	11	view →
LUSC	All	All	+0.308	.003	5	view →
KIRC	All	All	+0.003	.019	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

STATH–HNSC

Open the HNSC breakdown →