STATH

Across TCGA patient cohorts, STATH mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STATH-associated genes across cancer lineages are RN7SL759P, HMGN1P32, and LINC00544. Each is linked with STATH in more than 1 cancer types. Because this analysis shows association rather than direction, both STATH-to-partner and partner-to-STATH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL759P grouped by STATH-low versus STATH-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STATH→partner) and Y-score (partner→STATH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RN7SL759P →	+0.154	+7.977	<.001	.007	3	2
UCEC	HMGN1P32 →	+0.200	+3.523	.001	.001	3	2
UCEC	LINC00544 →	+0.104	+3.218	.006	.003	3	1
LGG	OR10R2 →	+0.034	+7.977	<.001	.007	3	1
LGG	MIR449B →	+0.388	+7.977	<.001	.007	3	1
LGG	MIR873 →	+0.253	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

RN7SL759P by STATH expression — LGG

Explore this box plot interactively →