STAT5B

Across TCGA patient cohorts, STAT5B mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAT5B-associated genes across cancer lineages are FoxM1, INPP4B, and ASNS. Each is linked with STAT5B in more than 1 cancer types. Because this analysis shows association rather than direction, both STAT5B-to-partner and partner-to-STAT5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by STAT5B-low versus STAT5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT5B→partner) and Y-score (partner→STAT5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.229	+2.321	.032	.006	3	2
UCEC	INPP4B →	-0.329	-3.321	.013	.009	3	2
UCEC	ASNS →	+0.300	+2.321	.045	.034	3	2
UCEC	ATM →	-0.478	-3.156	.010	.018	3	2
UCEC	CDK1_pY15 →	+0.231	+3.343	.008	.005	3	2
STAD	alpha-Catenin →	+0.295	+3.169	.023	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

FoxM1 by STAT5B expression — UCEC

Explore this box plot interactively →