STAT5B

Across TCGA pan-cancer cohorts, STAT5B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of STAT5B’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where STAT5B RNA is repressed in tumor relative to normal tissue. In most cancer types STAT5B is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

BLCA, LUSC, and LUAD are the cancer types where STAT5B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STAT5B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−1.674	<.001	8	view →
LUSC	Male	All	−0.711	<.001	8	view →
LUAD	Female	III,IV	−0.848	<.001	7	view →
UCEC	All	All	−1.978	<.001	6	view →
BRCA	All	III,IV	−1.297	<.001	6	view →
LIHC	All	II,III,IV	+0.468	<.001	6	view →
CHOL	All	All	+0.901	<.001	5	view →
KICH	All	All	−0.676	<.001	5	view →
KIRC	All	All	+0.318	<.001	5	view →
HNSC	Female	All	+0.524	.006	4	view →
PRAD	All	All	−0.417	<.001	2	view →
ESCA	All	All	+0.661	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

STAT5B–BLCA

Open the BLCA breakdown →