STAT5B

Across TCGA cell cohorts, STAT5B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,968 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STAT5B-associated GO terms across cancer lineages are Growth hormone receptor signaling pathway via JAK-STAT, Positive regulation of erythrocyte differentiation, and Cytosolic transport. Each is linked with STAT5B in more than 16 cancer types. Because this analysis shows association rather than direction, both STAT5B-to-partner and partner-to-STAT5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Growth hormone receptor signaling pathway via JAK-STAT grouped by STAT5B-low versus STAT5B-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT5B→partner) and Y-score (partner→STAT5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Growth hormone receptor signaling pathway via JAK-STAT →	+0.184	+1.142	<.001	<.001	3	17
OESOPHAGUS	Positive regulation of erythrocyte differentiation →	+0.142	+1.095	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.071	+1.063	<.001	<.001	3	13
LARGE_INTESTINE	Negative regulation of DNA-templated transcription initiation →	+0.111	+0.682	<.001	.001	3	13
PANCREAS	Interleukin-23-mediated signaling pathway →	+0.211	+1.030	<.001	<.001	3	13
STOMACH	Microtubule nucleation →	+0.107	+0.876	.006	.005	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,968 associations by consensus.

Growth hormone receptor signaling pathway via JAK-STAT by STAT5B expression — BLOOD_Leukemia

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