STAT5B

Across TCGA cell cohorts, STAT5B mutation is significantly associated with the RNA expression of many other genes, with 314 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STAT5B-associated genes across cancer lineages are CDRT15L2, C9, and LRTM1. Each is linked with STAT5B in more than 1 cancer types. Because this analysis shows association rather than direction, both STAT5B-to-partner and partner-to-STAT5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDRT15L2 grouped by STAT5B-low versus STAT5B-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT5B→partner) and Y-score (partner→STAT5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CDRT15L2 →	+0.020	+4.807	<.001	.006	3	1
BLOOD_Leukemia	C9 →	+0.864	+3.544	.001	.008	3	1
BLOOD_Leukemia	LRTM1 →	+0.870	+3.234	<.001	.008	3	1
BLOOD_Leukemia	HCRT →	+0.130	+3.864	<.001	.003	3	1
BLOOD_Leukemia	DACT2 →	+0.012	+3.623	.004	.007	3	1
BLOOD_Leukemia	C2orf73 →	+0.046	+3.450	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 314 associations by consensus.

CDRT15L2 by STAT5B expression — BLOOD_Myeloma

Explore this box plot interactively →