STAT1

Across TCGA cell cohorts, STAT1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STAT1-associated genes across cancer lineages are ASZ1, CNGA2, and ANGPTL5. Each is linked with STAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAT1-to-partner and partner-to-STAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASZ1 grouped by STAT1-low versus STAT1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT1→partner) and Y-score (partner→STAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASZ1 →	+0.127	+4.152	<.001	.009	3	1
BLOOD_Leukemia	CNGA2 →	+0.074	+4.539	<.001	.007	3	1
BLOOD_Leukemia	ANGPTL5 →	+0.022	+4.276	.007	.007	3	1
LARGE_INTESTINE	LONRF2 →	+0.524	+3.392	<.001	.006	3	1
LARGE_INTESTINE	SFMBT2 →	+0.355	+3.285	.008	.007	3	1
LARGE_INTESTINE	TBC1D3 →	+0.043	+2.688	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ASZ1 by STAT1 expression — BLOOD_Leukemia

Explore this box plot interactively →