STARD8

Across TCGA patient cohorts, STARD8 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STARD8-associated genes across cancer lineages are Caspase-7-cleavedD198, Notch1, and ATM. Each is linked with STARD8 in more than 2 cancer types. Because this analysis shows association rather than direction, both STARD8-to-partner and partner-to-STARD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by STARD8-low versus STARD8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STARD8→partner) and Y-score (partner→STARD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.236	+3.178	.001	.010	3	3
UCEC	Notch1 →	+0.139	+1.402	<.001	.011	3	3
UCEC	ATM →	-0.676	-2.321	<.001	<.001	3	3
UCEC	C-Raf →	+0.124	+1.184	.003	.022	3	3
LUAD	MSH2 →	-0.311	-3.153	.030	.019	3	2
UCEC	4E-BP1 →	+0.281	+2.321	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Caspase-7-cleavedD198 by STARD8 expression — COAD

Explore this box plot interactively →