STAM2

Across TCGA cell cohorts, STAM2 mutation is significantly associated with the mutation status of many other genes, with 3,173 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STAM2-associated genes across cancer lineages are SETD2, NFAT5, and TEX11. Each is linked with STAM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both STAM2-to-partner and partner-to-STAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SETD2 grouped by STAM2-low versus STAM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAM2→partner) and Y-score (partner→STAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SETD2 →	+2.367	+3.372	.002	.002	1	4
BLOOD_Leukemia	NFAT5 →	+6.321	+6.321	.001	.001	1	3
SOFT_TISSUE	TEX11 →	+5.502	+5.502	.003	.003	1	3
SOFT_TISSUE	RPL5 →	+5.502	+5.502	.003	.003	1	3
SOFT_TISSUE	PREPL →	+5.502	+5.502	.003	.003	1	3
SOFT_TISSUE	RFWD3 →	+4.502	+5.066	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,173 associations by consensus.

SETD2 by STAM2 expression — LARGE_INTESTINE

Explore this box plot interactively →