STAM

Across TCGA pan-cancer cohorts, STAM Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated STAM data layer compared with 21 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher STAM Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated STAM expression acts as an unfavorable survival marker.

HNSC, BLCA, and SARC are the cancer types where STAM Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.078	0.710	<.001	24	view →
BLCA	OS	Median	All	0.217	0.610	.011	12	view →
SARC	DFS	Median	All	0.159	0.613	.015	6	view →
LGG	OS	Median	All	0.132	0.830	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

STAM–HNSC (DFS)

Open the HNSC breakdown →