STAM

Across TCGA pan-cancer cohorts, STAM RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of STAM’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where STAM RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STAM is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

LIHC, COAD, and KICH are the cancer types where STAM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STAM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.103	<.001	9	view →
COAD	Male	II,III,IV	+0.753	<.001	9	view →
KICH	Female	II,III,IV	−1.348	<.001	8	view →
HNSC	All	All	+0.385	.001	8	view →
THCA	Male	All	+0.616	<.001	6	view →
BRCA	All	II,III,IV	+0.370	<.001	6	view →
STAD	All	All	+0.583	<.001	4	view →
CHOL	Male	All	+2.088	<.001	3	view →
KIRP	Female	II,III,IV	+0.623	.008	2	view →
KIRC	All	II,III,IV	−0.231	.026	2	view →
LUAD	Female	All	−0.256	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

STAM–LIHC

Open the LIHC breakdown →