STAM

Across TCGA patient cohorts, STAM mutation is significantly associated with the RNA expression of many other genes, with 3,704 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAM-associated genes across cancer lineages are NIPA2P4, OR10R3P, and RNU6-1242P. Each is linked with STAM in more than 1 cancer types. Because this analysis shows association rather than direction, both STAM-to-partner and partner-to-STAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NIPA2P4 grouped by STAM-low versus STAM-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAM→partner) and Y-score (partner→STAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NIPA2P4 →	+0.111	+3.926	<.001	.005	3	2
BRCA	OR10R3P →	+0.039	+6.001	.004	<.001	3	2
LUSC	RNU6-1242P →	+0.352	+3.715	<.001	.008	3	2
CESC	MIR6806 →	+0.757	+4.409	<.001	.006	3	2
UCEC	RNU6-1318P →	+0.261	+2.621	<.001	<.001	3	2
UCEC	RPS15AP34 →	+0.130	+1.718	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,704 associations by consensus.

NIPA2P4 by STAM expression — LUAD

Explore this box plot interactively →