STAM

Across TCGA cell cohorts, STAM mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STAM-associated genes across cancer lineages are CBY1, FMO1, and MYF6. Each is linked with STAM in more than 1 cancer types. Because this analysis shows association rather than direction, both STAM-to-partner and partner-to-STAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by STAM-low versus STAM-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAM→partner) and Y-score (partner→STAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.824	+3.137	<.001	.007	3	1
LARGE_INTESTINE	FMO1 →	+0.117	+3.144	<.001	.001	3	1
LARGE_INTESTINE	MYF6 →	+0.007	+3.415	<.001	.001	3	1
LARGE_INTESTINE	C6orf118 →	+0.099	+2.793	<.001	.002	3	1
LARGE_INTESTINE	ZSCAN20 →	+0.551	+3.125	<.001	.008	3	1
LARGE_INTESTINE	FTHL17 →	+0.040	+3.415	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

CBY1 by STAM expression — LARGE_INTESTINE

Explore this box plot interactively →