STAM-AS1

Across TCGA pan-cancer cohorts, STAM-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of STAM-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where STAM-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STAM-AS1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

BLCA, HNSC, and COAD are the cancer types where STAM-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STAM-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+0.405	<.001	11	view →
HNSC	Male	III,IV	+0.229	<.001	11	view →
COAD	Male	IV	+0.548	<.001	10	view →
LIHC	Female	II,III,IV	+0.159	<.001	7	view →
UCEC	All	II,III,IV	+0.318	.009	6	view →
BRCA	All	III,IV	+0.208	<.001	6	view →
CHOL	Male	All	+0.713	<.001	5	view →
READ	All	II,III,IV	+0.382	.001	5	view →
LUSC	All	All	+0.261	<.001	5	view →
KICH	All	All	−0.435	<.001	4	view →
THCA	All	All	+0.194	<.001	4	view →
STAD	All	All	+0.194	.003	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

STAM-AS1–BLCA

Open the BLCA breakdown →