STAG3L4

Across TCGA patient cohorts, STAG3L4 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAG3L4-associated genes across cancer lineages are JNK_pT183_Y185, JNK2, and MEK1. Each is linked with STAG3L4 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAG3L4-to-partner and partner-to-STAG3L4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by STAG3L4-low versus STAG3L4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAG3L4→partner) and Y-score (partner→STAG3L4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.233	-3.169	.004	.019	3	1
UCEC	JNK2 →	+0.280	+3.179	.003	.010	3	1
UCEC	MEK1 →	+0.466	+2.999	.008	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.646	-2.446	.002	.020	3	1
UCEC	p62 Lck ligand →	+0.390	+3.009	.013	.019	3	1
UCEC	p70-S6K_pT389 →	-0.201	-3.584	.028	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

JNK_pT183_Y185 by STAG3L4 expression — UCEC

Explore this box plot interactively →