STAG3L4

Across TCGA pan-cancer cohorts, STAG3L4 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated STAG3L4 data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher STAG3L4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated STAG3L4 expression acts as an unfavorable survival marker, although some lineages such as PAAD and DLBC show a favorable association.

COAD, ACC, and HNSC are the cancer types where STAG3L4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.478	0.669	<.001	104	view →
ACC	DFS	Quartile	All	0.133	0.645	<.001	44	view →
HNSC	DFS	Quartile	All	0.639	0.732	.015	31	view →
PAAD	OS	Median	All	0.533	0.251	.002	28	view →
LIHC	OS	Quartile	All	0.692	0.837	.007	28	view →
UVM	DFS	Median	III,IV	0.275	0.702	.009	27	view →
STAD	DFS	Median	IV	0.316	0.620	.022	23	view →
KICH	OS	Quartile	II,III,IV	0.520	1.000	.005	20	view →
ESCA	DFS	Tertile	IV	0.143	0.704	.024	18	view →
READ	OS	Median	III,IV	0.786	1.000	.002	18	view →
PRAD	DFS	Tertile	All	0.624	0.866	.002	14	view →
LGG	OS	Quartile	All	0.857	0.946	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

STAG3L4–COAD (OS)

Open the COAD breakdown →