STAG3L3

Across TCGA patient cohorts, STAG3L3 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAG3L3-associated genes across cancer lineages are UBE2Q2P10, OR5M14P, and RNA5SP162. Each is linked with STAG3L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAG3L3-to-partner and partner-to-STAG3L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2Q2P10 grouped by STAG3L3-low versus STAG3L3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAG3L3→partner) and Y-score (partner→STAG3L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	UBE2Q2P10 →	+0.045	+5.010	<.001	.009	3	1
CESC	OR5M14P →	+0.065	+5.539	<.001	.004	3	1
CESC	RNA5SP162 →	+0.623	+5.103	<.001	.008	3	1
CESC	RNA5SP367 →	+0.284	+5.010	.003	.009	3	1
CESC	ELOCP32 →	+0.185	+5.010	<.001	.009	3	1
CESC	MIR4646 →	+0.607	+5.103	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

UBE2Q2P10 by STAG3L3 expression — CESC

Explore this box plot interactively →