STAG3L3

Across TCGA pan-cancer cohorts, STAG3L3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated STAG3L3 data layer compared with 2 for mutation status.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher STAG3L3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated STAG3L3 expression acts as an unfavorable survival marker, although some lineages such as UCS and LAML show a favorable association.

UCS, LGG, and KIRC are the cancer types where STAG3L3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Quartile	II,III,IV	0.779	0.163	.001	94	view →
LGG	DFS	Median	All	0.654	0.814	<.001	50	view →
KIRC	DFS	Quartile	III,IV	0.230	0.553	.004	47	view →
UVM	DFS	Tertile	III,IV	0.186	0.841	.001	44	view →
COAD	OS	Median	All	0.739	0.863	.006	39	view →
LAML	DFS	Quartile	All	0.716	0.384	<.001	34	view →
KICH	OS	Quartile	All	0.687	1.000	.012	22	view →
PRAD	DFS	Median	All	0.848	0.920	.009	22	view →
READ	OS	Median	II,III,IV	0.854	0.283	.002	19	view →
UCEC	DFS	Median	All	0.860	0.930	.002	18	view →
BRCA	OS	Quartile	IV	0.645	0.122	.008	17	view →
ACC	DFS	Median	All	0.316	0.598	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

STAG3L3–UCS (OS)

Open the UCS breakdown →