STAG3

Across TCGA patient cohorts, STAG3 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAG3-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and Bad_pS112. Each is linked with STAG3 in more than 3 cancer types. Because this analysis shows association rather than direction, both STAG3-to-partner and partner-to-STAG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by STAG3-low versus STAG3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAG3→partner) and Y-score (partner→STAG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.372	+3.330	<.001	.005	2	4
UCEC	ATM →	-0.618	-1.807	<.001	<.001	3	3
COAD	Bad_pS112 →	-0.207	-3.313	.025	.010	3	2
UCEC	eEF2 →	+0.227	+1.807	.033	.024	3	2
UCEC	ERK2 →	+0.148	+1.392	.010	.017	3	2
UCEC	FoxM1 →	+0.208	+1.584	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Caspase-7-cleavedD198 by STAG3 expression — COAD

Explore this box plot interactively →