STAG3

Across TCGA pan-cancer cohorts, STAG3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of STAG3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where STAG3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STAG3 is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

KIRC, KIRP, and BRCA are the cancer types where STAG3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STAG3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.440	<.001	11	view →
KIRP	All	All	+0.598	<.001	8	view →
BRCA	All	III,IV	−0.411	<.001	6	view →
HNSC	All	II,III,IV	+0.491	.005	5	view →
UCEC	All	All	−0.797	<.001	4	view →
KICH	Male	III,IV	−0.572	.008	3	view →
CHOL	Female	All	+1.120	.010	2	view →
STAD	All	II,III,IV	+0.449	.022	2	view →
BLCA	Male	IV	−0.375	.048	1	view →
LUAD	All	All	+0.366	.014	1	view →
LUSC	All	All	+0.301	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

STAG3–KIRC

Open the KIRC breakdown →