STAG3

Across TCGA cell cohorts, STAG3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,461 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible STAG3-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with STAG3 in more than 13 cancer types. Because this analysis shows association rather than direction, both STAG3-to-partner and partner-to-STAG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by STAG3-low versus STAG3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STAG3→partner) and Y-score (partner→STAG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of myoblast fusion →	+0.126	+1.723	<.001	<.001	3	14
BONE	Negative regulation of syncytium formation by plasma membrane fusion →	+0.124	+1.674	<.001	<.001	3	14
BONE	Regulation of syncytium formation by plasma membrane fusion →	+0.103	+1.898	<.001	<.001	3	14
BONE	Regulation of myoblast fusion →	+0.114	+2.006	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of autophagy →	+0.080	+1.373	<.001	<.001	3	13
LIVER	Regulation of translational initiation →	+0.101	+1.310	<.001	.003	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,461 associations by consensus.

Negative regulation of myoblast fusion by STAG3 expression — BONE

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