STAG3

Across TCGA cell cohorts, STAG3 mutation is significantly associated with the RNA expression of many other genes, with 1,398 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STAG3-associated genes across cancer lineages are OR10A4, PPP4R3A, and YWHAE. Each is linked with STAG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAG3-to-partner and partner-to-STAG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A4 grouped by STAG3-low versus STAG3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAG3→partner) and Y-score (partner→STAG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR10A4 →	+0.037	+4.217	.002	.005	3	2
BLOOD_Leukemia	PPP4R3A →	+0.494	+3.259	.007	.006	3	2
BLOOD_Leukemia	YWHAE →	+0.576	+3.199	.009	.007	3	2
BLOOD_Leukemia	TTC33 →	+0.842	+3.318	<.001	.005	3	2
BLOOD_Leukemia	DYNC2I2 →	+0.966	+3.259	.003	.006	3	2
BLOOD_Leukemia	TEX14 →	+0.343	+3.199	.005	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,398 associations by consensus.

OR10A4 by STAG3 expression — URINARY_TRACT

Explore this box plot interactively →