STAG2

Across TCGA cell cohorts, STAG2 mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STAG2-associated genes across cancer lineages are BPIFA2, MBD3L4, and NEXMIF. Each is linked with STAG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAG2-to-partner and partner-to-STAG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFA2 grouped by STAG2-low versus STAG2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAG2→partner) and Y-score (partner→STAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	BPIFA2 →	+0.886	+4.217	.003	.005	3	2
URINARY_TRACT	MBD3L4 →	+0.020	+4.087	<.001	.009	3	2
BLOOD_Leukemia	NEXMIF →	+0.485	+3.614	.003	.004	3	2
LUNG_SCLC	IFNA2 →	+0.022	+5.029	<.001	.006	3	2
BLOOD_Lymphoma	HTR3D →	+0.007	+3.662	<.001	.009	3	2
BLOOD_Leukemia	SPATA19 →	+0.011	+3.984	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

BPIFA2 by STAG2 expression — URINARY_TRACT

Explore this box plot interactively →