STAC

Across TCGA patient cohorts, STAC mutation is significantly associated with the RNA expression of many other genes, with 1,912 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAC-associated genes across cancer lineages are RNU6-768P, CCDC58P1, and CIDECP1. Each is linked with STAC in more than 2 cancer types. Because this analysis shows association rather than direction, both STAC-to-partner and partner-to-STAC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-768P grouped by STAC-low versus STAC-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAC→partner) and Y-score (partner→STAC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-768P →	+0.868	+4.814	<.001	.003	3	3
SKCM	CCDC58P1 →	+0.072	+1.391	.003	.008	3	3
SKCM	CIDECP1 →	+0.441	+2.623	<.001	<.001	3	3
SKCM	RPA2 →	+0.324	+1.880	.009	.001	3	3
BLCA	MIR1263 →	+0.259	+5.632	<.001	.001	3	3
ESCA	RNA5SP308 →	+0.560	+5.068	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,912 associations by consensus.

RNU6-768P by STAC expression — BLCA

Explore this box plot interactively →