STAC

Across TCGA pan-cancer cohorts, STAC RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of STAC’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where STAC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STAC is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

THCA, KIRC, and LUSC are the cancer types where STAC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STAC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	+2.812	<.001	11	view →
KIRC	All	III,IV	−0.700	<.001	11	view →
LUSC	All	III,IV	−3.378	<.001	8	view →
BLCA	Male	IV	−2.847	.001	8	view →
LUAD	Female	III,IV	−2.215	<.001	8	view →
UCEC	All	III,IV	−2.126	<.001	8	view →
HNSC	Female	III,IV	+0.972	<.001	7	view →
BRCA	All	III,IV	−1.540	<.001	6	view →
COAD	Male	All	−0.537	.011	4	view →
READ	Female	All	−2.194	.009	2	view →
PRAD	All	All	−1.638	<.001	2	view →
KIRP	Male	All	−0.687	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

STAC–THCA

Open the THCA breakdown →