STAC

Across TCGA cell cohorts, STAC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,925 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible STAC-associated GO terms across cancer lineages are Positive regulation of cytoskeleton organization, Regulation of cell-substrate junction assembly, and Neuroligin clustering involved in postsynaptic membrane assembly. Each is linked with STAC in more than 11 cancer types. Because this analysis shows association rather than direction, both STAC-to-partner and partner-to-STAC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytoskeleton organization grouped by STAC-low versus STAC-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STAC→partner) and Y-score (partner→STAC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of cytoskeleton organization →	+0.059	+2.048	<.001	.001	3	12
BONE	Regulation of cell-substrate junction assembly →	+0.174	+2.011	<.001	<.001	3	10
BONE	Neuroligin clustering involved in postsynaptic membrane assembly →	+1.220	+1.614	<.001	.001	3	10
BONE	Positive regulation of focal adhesion assembly →	+0.203	+2.000	<.001	<.001	3	10
STOMACH	Positive regulation of supramolecular fiber organization →	+0.087	+1.938	.001	.002	3	10
LIVER	Regulation of plasminogen activation →	+0.363	+2.997	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,925 associations by consensus.

Positive regulation of cytoskeleton organization by STAC expression — LUNG_SCLC

Explore this box plot interactively →