STAB2

Across TCGA patient cohorts, STAB2 mutation is significantly associated with the RNA expression of many other genes, with 10,328 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAB2-associated genes across cancer lineages are SKP2, VTA1, and ERI1. Each is linked with STAB2 in more than 5 cancer types. Because this analysis shows association rather than direction, both STAB2-to-partner and partner-to-STAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKP2 grouped by STAB2-low versus STAB2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAB2→partner) and Y-score (partner→STAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SKP2 →	+0.686	+1.748	<.001	<.001	3	6
STAD	VTA1 →	+0.420	+3.235	.005	.008	3	6
STAD	ERI1 →	+0.661	+3.186	<.001	.009	3	6
UCEC	ZWILCH →	+0.503	+1.262	<.001	<.001	3	6
UCEC	RRM1 →	+0.788	+1.667	<.001	<.001	3	6
STAD	TIMM21 →	+0.536	+2.824	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,328 associations by consensus.

SKP2 by STAB2 expression — LUAD

Explore this box plot interactively →