STAB2

Across TCGA pan-cancer cohorts, STAB2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated STAB2 data layer compared with 11 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher STAB2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated STAB2 expression acts as an unfavorable survival marker, although some lineages such as SCLC and BRCA show a favorable association.

UVM, ACC, and SCLC are the cancer types where STAB2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.315	0.811	<.001	113	view →
ACC	DFS	Median	III,IV	0.117	0.650	<.001	102	view →
SCLC	DFS	Tertile	III,IV	0.800	0.282	<.001	68	view →
BRCA	OS	Median	III,IV	0.698	0.416	.001	47	view →
HNSC	DFS	Median	II,III,IV	0.756	0.635	.005	46	view →
KIRP	DFS	Median	All	0.780	0.919	<.001	46	view →
COAD	DFS	Median	III,IV	0.577	0.743	.003	39	view →
STAD	DFS	Quartile	All	0.494	0.636	.011	38	view →
MESO	DFS	Median	IV	0.474	0.153	.001	36	view →
UCEC	DFS	Median	IV	0.910	0.490	.001	20	view →
KIRC	DFS	Tertile	IV	0.164	0.376	.012	18	view →
ESCA	OS	Tertile	III,IV	0.604	0.283	.003	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

STAB2–UVM (DFS)

Open the UVM breakdown →