STAB1

Across TCGA patient cohorts, STAB1 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAB1-associated genes across cancer lineages are EGFR, PCNA, and Rad50. Each is linked with STAB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both STAB1-to-partner and partner-to-STAB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by STAB1-low versus STAB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAB1→partner) and Y-score (partner→STAB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.095	-1.781	.033	.024	3	3
UCEC	PCNA →	+0.163	+1.678	.006	<.001	3	3
UCEC	Rad50 →	-0.156	-1.489	.020	.025	3	3
UCEC	XBP1 →	-0.110	-1.349	.005	.031	3	3
UCEC	ATM →	-0.535	-1.874	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.810	+1.874	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

EGFR by STAB1 expression — UCEC

Explore this box plot interactively →