STAB1

Across TCGA pan-cancer cohorts, STAB1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated STAB1 data layer compared with 10 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher STAB1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated STAB1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, KIRP, and UVM are the cancer types where STAB1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.683	0.497	<.001	84	view →
KIRP	OS	Median	All	0.900	0.962	.006	56	view →
UVM	OS	Tertile	All	0.403	0.769	.005	47	view →
LUAD	OS	Quartile	II,III,IV	0.889	0.629	.001	42	view →
OV	OS	Tertile	III,IV	0.781	0.905	.001	38	view →
UCS	DFS	Tertile	IV	0.938	0.237	.024	30	view →
STAD	OS	Quartile	All	0.283	0.629	.012	22	view →
LUSC	DFS	Tertile	All	0.299	0.492	.016	20	view →
CHOL	DFS	Median	All	0.614	0.200	.015	18	view →
LGG	DFS	Median	All	0.324	0.463	.002	16	view →
BRCA	DFS	Tertile	All	0.858	0.919	.002	16	view →
SKCM	OS	Median	II,III,IV	0.411	0.212	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

STAB1–HNSC (DFS)

Open the HNSC breakdown →