ST8SIA6

Across TCGA pan-cancer cohorts, ST8SIA6 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ST8SIA6 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ST8SIA6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ST8SIA6 expression acts as an unfavorable survival marker.

KIRP, PAAD, and READ are the cancer types where ST8SIA6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.176	0.885	<.001	24	view →
PAAD	OS	Median	All	0.117	0.613	<.001	21	view →
READ	DFS	Median	All	0.182	0.798	.010	9	view →
SCLC	DFS	Median	II,III,IV	0.205	0.610	.028	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ST8SIA6–KIRP (OS)

Open the KIRP breakdown →