ST8SIA5

Across TCGA patient cohorts, ST8SIA5 mutation is significantly associated with the RNA expression of many other genes, with 2,374 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST8SIA5-associated genes across cancer lineages are CLN6, RABL6, and SNRNP25. Each is linked with ST8SIA5 in more than 3 cancer types. Because this analysis shows association rather than direction, both ST8SIA5-to-partner and partner-to-ST8SIA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLN6 grouped by ST8SIA5-low versus ST8SIA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST8SIA5→partner) and Y-score (partner→ST8SIA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CLN6 →	+0.302	+2.555	.006	<.001	3	4
UCEC	RABL6 →	+0.356	+2.008	.001	.001	3	3
UCEC	SNRNP25 →	+0.428	+1.968	<.001	<.001	3	3
UCEC	STOML2 →	+0.395	+1.893	.001	<.001	3	3
UCEC	ZFYVE19 →	+0.505	+2.180	<.001	<.001	3	3
UCEC	DTYMK →	+0.458	+2.094	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,374 associations by consensus.

CLN6 by ST8SIA5 expression — UCEC

Explore this box plot interactively →