ST8SIA3

Across TCGA pan-cancer cohorts, ST8SIA3 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated ST8SIA3 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ST8SIA3 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ST8SIA3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, LUSC, and SCLC are the cancer types where ST8SIA3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.301	.002	34	view →
LUSC	DFS	Median	II,III,IV	0.079	0.749	.010	18	view →
SCLC	OS	Median	All	0.082	0.822	<.001	18	view →
LGG	OS	Median	All	0.133	0.811	<.001	12	view →
LIHC	DFS	Median	All	0.107	0.557	<.001	12	view →
COAD	OS	Median	III,IV	0.145	0.780	.008	9	view →
CESC	OS	Median	II,III,IV	0.524	0.829	.035	6	view →
BLCA	OS	Median	All	0.445	0.722	.039	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SARC	DFS	Median	All	0.179	0.594	.031	3	view →
SKCM	OS	Median	II,III,IV	0.955	0.830	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

ST8SIA3–UCEC (DFS)

Open the UCEC breakdown →