ST8SIA2

Across TCGA pan-cancer cohorts, ST8SIA2 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ST8SIA2 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ST8SIA2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ST8SIA2 expression acts as an unfavorable survival marker.

COAD, LIHC, and LAML are the cancer types where ST8SIA2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	III,IV	0.133	0.783	<.001	23	view →
LIHC	DFS	Median	All	0.166	0.557	.009	15	view →
LAML	DFS	Median	All	0.082	0.582	.004	12	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	12	view →
LUAD	OS	Median	III,IV	0.158	0.663	.008	12	view →
BLCA	OS	Median	All	0.188	0.687	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ST8SIA2–COAD (OS)

Open the COAD breakdown →