ST8SIA1

Across TCGA pan-cancer cohorts, ST8SIA1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ST8SIA1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ST8SIA1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ST8SIA1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, THCA, and SKCM are the cancer types where ST8SIA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.438	.016	28	view →
THCA	DFS	Median	All	0.070	0.896	<.001	18	view →
SKCM	DFS	Median	II,III,IV	0.037	0.683	<.001	15	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ST8SIA1–UCEC (DFS)

Open the UCEC breakdown →