Across TCGA pan-cancer cohorts, ST7-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ST7-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ST7-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ST7-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and KIRC are the cancer types where ST7-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST7-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.585	<.001	11	view →
KICH	Male	All	−1.560	<.001	10	view →
KIRC	Male	II,III,IV	−0.812	<.001	9	view →
LUAD	All	II,III,IV	−0.803	<.001	9	view →
LIHC	Female	All	+0.514	<.001	7	view →
BRCA	All	III,IV	−1.046	<.001	6	view →
LUSC	Male	All	−0.600	<.001	5	view →
KIRP	All	All	−0.450	.009	4	view →
BLCA	Male	IV	−1.157	.004	2	view →
UCEC	All	All	−0.555	.017	2	view →
CHOL	Male	All	+0.510	<.001	2	view →
PRAD	All	All	−0.278	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

Exploration

Same gene, other analysis: ST7-AS1 RNA expression & survival · all ST7-AS1 data types